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What are GLP-1/GIP Peptides?

Semaglutide+B12 and Tirzepatide+B12, also called glucagon-like peptide-1 receptor agonists or GLP-1/GIP, mimic our natural hormones that are released when we eat. They target the brain center that regulates appetite reducing the sensation of hunger and increasing the sensation of fullness resulting in less overeating and, lower calorie intake. They also reduce your blood sugar level, the rate sugar appears in your circulation, and delays how fast your stomach empties contributing to that sensation of fullness.

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Semaglutide+Cyanocobalamin (B12)

Semaglutide is the compounded formulation of the brand name medications Ozempic® and Wegovy®.

Key Facts:

Semaglutide is a medication used to treat Type 2 diabetes and obesity. It belongs to a class of drugs called GLP-1 receptor agonists (glucagon-like peptide-1 receptor agonists).

Drug class: GLP-1 receptor agonist (glucagon-like peptide-1)

  • It mimics the GLP-1 hormone, which helps regulate blood sugar levels and appetite.

How It Works:

Semaglutide mimics the action of the natural hormone GLP-1, which:

  • Increases insulin release (when blood sugar is high)

  • Decreases the amount of sugar the liver releases

  • Slows down gastric emptying (how quickly food leaves the stomach)

  • Reduces appetite and food intake

Administration:

  • Given as a once weekly subcutaneous injection

Tirzepatide+Cyanocobalamin (B12)

Tirzepatide is the compounded formulation of the brand name medications Mounjaro® and Zepbound®.

Key Facts:

  • Drug class: Tirzepatide is a dual GIP and GLP-1 receptor agonist.

    • GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) are hormones that help regulate blood sugar and appetite.

    • By mimicking both, tirzepatide improves blood sugar control and promotes weight loss.​

How it Works:

  • Increases insulin secretion when blood sugar is high.

  • Suppresses appetite and slows gastric emptying.

  • Reduces glucagon secretion (a hormone that raises blood sugar).

Administration:

  • Given as a once-weekly subcutaneous injection.

Tirzepatide + Niacinamide (B3) medication information basics

The FDA-approved uses of GLP-1 receptor agonists for weight loss are specifically tied to chronic weight management in individuals who meet defined criteria.

Semaglutide:  To be eligible for FDA-approved GLP-1 weight loss treatment, patients must fall into one of these categories: BMI ≥30 (obesity), or BMI ≥27 (overweight) plus at least one weight-related condition: Type 2 diabetes, Hypertension, Dyslipidemia (high cholesterol), Obstructive sleep apnea, etc.

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Tirzepatide: Adults with obesity (BMI ≥30), or overweight (BMI ≥27) + at least one weight-related condition: Type 2 diabetes, Hypertension, Dyslipidemia (high cholesterol), Obstructive sleep apnea, Cardiovascular disease, Insulin resistance or prediabetes, PCOS (Polycystic Ovary Syndrome), etc.

These approvals apply only to specific drugs and doses—not the entire GLP-1 class. 

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Allowable use of Compounded GLP-1/GIP:

  • The patient receives a significant clinical difference from improved metabolic control provided by Vitamin B and from the increase compliance due to a single vs. double injection.

  • Patient has a Vitamin B deficiency and receives a significant clinical difference from supplementation and from the increased compliance due to single vs. double injection.

  • Patient receives a significant clinical difference from Vitamin B supplementation, as the GLP1-RA's delayed gastric emptying may impact nutrient absorption, and from the increased compliance due to a single vs. double injection

  • Patient receives a significant clinical difference from Vitamin B's role in energy metabolism to address fatigue, weakness, and neuropathy, and from the increased compliance due to single vs. double injection.

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This Compounded medication is prepared by a licensed compounding pharmacy based on the provider's prescription.  Disclaimer: The FDA does not approve nor review compounded products for safety, effectiveness, or quality. 

Compounded Medication Source Information

Weight Benefits-503A Compounding Pharmacy Source Information

At Weight Benefits, your health and safety are our highest priorities. We are committed to sourcing only the highest-quality compounded GLP-1/GIP (glucagon-like peptide) medications that are made only in the USA. When it comes to your care, consistency and reliability are non-negotiable.

We only work with and source with regulated compounding partners that follow strict standards for purity, potency, and safety. Approximately 1% of compounding pharmacies choose to test every batch they compound for sterility and potency, maintaining the highest standard of safety. When this third-party testing is performed, it takes about 10 days to receive the results for sterility, potency, and the medications are never released until these tests have been passed and confirmed.  Only pharmaceutical grade ingredients sourced from FDA registered facilities are used in preparing all compounds. By choosing domestically compounded medications, we not only support transparent and regulated manufacturing practices, but also ensure that you receive a medication you can trust.​

Question: What is a 503A vs. 503B Compounding Pharmacy?

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Answer:  A 503A pharmacy refers to a type of compounding pharmacy regulated under Section 503A of the Federal Food, Drug, and Cosmetic Act (FDCA) in the United States. These pharmacies are allowed to compound medications for individual patients based on a valid prescription.

In Contrast:

503B pharmacy outsourcing facilities are allowed to compound medications in bulk without patient-specific prescriptions and are regulated directly by the FDA.​

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​​​Question: Does Weight Benefits 503A Compounding Pharmacy Perform Sterility Testing on its Compounded Sterile Medications?​​

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Answer:  Yes, our 503A Pharmacy partner has contracted a third-party analytical lab to conduct sterility, endotoxin, and potency testing on compounded medications in accordance with USP <71> Sterility Test and USP <85> Bacterial Endotoxin.
What other measures does the compounding pharmacy take to ensure the quality of service and the quality of compounded medications?
Our compounding pharmacy far exceeds the guidelines of USP <797> And USP <795> in an effort to exceed the expectations of patients and providers. They also have systems, procedures and processes in place, such as:

  • ADR reporting system with an ability to analyze trends and implement a corrective action plan if necessary

  • Formal Drug Recall System

  • Biannual reviews of Standard Operating Procedures

  • Certificate of Analysis is obtained for every chemical received by the pharmacy

  • Mandatory continuing education for all team members on the latest compounding trends and procedures

  • Formal Customer Incident Management systems consisting of a formal investigation of
    the incident and a corrective/preventative action plan

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Question: Does Weight Benefits 503B Compounding Pharmacy Perform Sterility Testing on its Compounded Sterile Medications?​​

 

Answer:  Yes, our 503B Pharmacy partner has contracted a third-party analytical lab to conduct sterility, endotoxin, and potency testing on compounded medications in accordance with USP <71> Sterility Test and USP <85> Bacterial Endotoxin.
What other measures does the compounding pharmacy take to ensure the quality of service and the quality of compounded medications?
Our compounding pharmacy far exceeds the guidelines of USP <797> And USP <795> in an effort to exceed the expectations of patients and providers. They also have systems, procedures and processes in place, such as:

  • ADR reporting system with an ability to analyze trends and implement a corrective action plan if necessary

  • Formal Drug Recall System

  • Biannual reviews of Standard Operating Procedures

  • Certificate of Analysis is obtained for every chemical received by the pharmacy

  • Mandatory continuing education for all team members on the latest compounding trends and procedures

  • Formal Customer Incident Management systems consisting of a formal investigation of
    the incident and a corrective/preventative action plan

Key Features of a 503B Pharmacy:

Our 503B Pharmacy is committed to quality, safety, and regulatory compliance. All of our products undergo rigorous third-party testing through qualified and independent laboratories to ensure they meet established standards for purity, potency, and consistency. These measures are part of our ongoing quality assurance protocols designed to provide full transparency and reliability. Additionally, the 503B pharmacy confirms that the active pharmaceutical ingredient (API) used in our formulations is sourced exclusively from suppliers listed on the FDA’s approved (“green list”) database. Pharmacy representatives visit the sites to do a supplier/vendor qualification.  This ensures that all materials originate from facilities that meet strict regulatory and manufacturing standards.

All medications are dispensed by a licensed 503A or 503B compounded pharmacy upon an individual prescription from a qualified provider following an in-person consultation.

Pharmacy Source: VitalRX NPI 1750078242, Akina NPI 1548693922

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