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Weight Benefits NAD+

What is NAD+ Injectable?

Compounded NAD+ Injectable is a formulation containing Nicotinamide Adenine Dinucleotide (NAD+), which may be used to enhance energy levels, improve concentration, and promote cellular and overall health. NAD+ is a crucial molecule found in all cells, necessary for cell function and viability.1,2 It is essential for cellular respiration, protein modification, the manufacture of cholesterol and nucleic acids, and calcium signaling. The body naturally produces NAD+ from the amino acid tryptophan and vitamin B3 precursors like nicotinic acid and nicotinamide.3

NAD is a coenzyme found in living cells, this coenzyme decreases with age. The plus sign in NAD+ refers to its oxidized form and indicates a positive charge on the molecule.

What May It Be Used For?

NAD+ levels tend to decrease with age due to certain factors, including oxidative stress and inflammation. Low NAD+ levels have been associated with various age-related diseases and conditions such as vision

loss, diabetes, heart disease, and Alzheimer's disease.4 In addition to aging, NAD+ depletion is also linked to addiction.5,6

Research suggests that NAD+ replacement therapy may have potential benefits for mitochondrial function, genomic stability, neuroprotection, longevity, and addiction treatment.2,4–6

Hence, Compounded NAD+ Injectable may be used to:

Treat chronic fatigue syndrome.
Support cellular energy production.
Enhance athletic performance and recovery.
Aid in addiction recovery by relieving withdrawal symptoms.
Promote anti-aging benefits by improving cellular health.7

How Does It Work?

NAD+ is a crucial coenzyme found in all living cells, playing a significant role in energy production and metabolic processes. It is involved in cellular respiration, converting nutrients into energy and participating in DNA repair, gene expression regulation, and cell signaling, contributing to overall cellular health and longevity.8

Compounded NAD+ injections may prevent mitochondrial malfunction, sustain metabolic function, and counteract age-related NAD+ degradation. This could potentially restore metabolic profiles, improve mitochondrial health, and delay accelerated aging, promoting overall mitochondrial and metabolic health. NAD+ supports various metabolic pathways through NAD+-dependent enzymes, influencing cellular functions and aging.8

Dosage Strengths

Compounded NAD+ Injectable is available from Weight Benefits in the following dosage strengths:

Starting dose of NAD+ 25mg to 50mg – Injectable, 2-3 times a week, if no adverse reactions are reported a gradual increase to 75md to 100mg, some protocols go up to 200mg but are reserved for therapeutic and clinical condition use. Use should be decreased if you experience nausea, flushing or prolonged fatigue.
Cycles consist of 4-6 weeks on followed by 2-4 weeks off, this helps avoid receptor downregulation and maintain effectiveness.
Taking a 4-6 weeks on 4-6 weeks off approach allows your body to stabilize NAD+ levels naturally, reduces the risk of tolerance or diminishing returns when your body slows its own production. Cycling helps maintain sensitivity and effectiveness of NAD+ pathways.

There isn’t a magic number that will suit everyone’s NAD+ needs. Finding the right NAD+ dose will depend on your health goals, lifestyle and how your body responds to the supplementation.

How Can NAD+ Levels Be Tested?

NAD+ testing can be performed by ordering a High-Performance Liquid Chromatography (HPLC) blood test.

At Home test kits can be found at:

Mynadtest.com
Jinfiniti.com

This kit uses a method that you can do on your own or by a weight benefits staff member and results are returned in 1-2 weeks. Cost is $100-$200

HPLC Testing

How Is It Administered?

NAD⁺ (Nicotinamide Adenine Dinucleotide) may be administered subcutaneously (the fatty tissue under the skin, e.g., abdomen) which offers a distinct advantage by bypassing the digestive system.

Storage

Storage is straight forward, keep refrigerated and, use by the "best used by" date.

Side Effects

Compounded NAD+ injection is considered to be safe and well-tolerated.9 However, there are potential side effects and adverse reactions that may include:

Common Side Effects:

Headache
Nausea/digestive upset
Dizziness
Fatigue
Shortness of breath
Diarrhea
Flushing or warmth sensation
Muscle cramps
Injection site reactions such as pain, redness, and swelling

Adverse Drug Reactions Requiring Medical Attention:

Increased plasma bilirubin
Decreased levels of gamma glutamyl transferase, lactate dehydrogenase and aspartate aminotransferase 9,10
Rash, itching, swelling
Difficulty breathing
Chest pain or fainting
Sign of liver stress (e.g., jaundice, dark urine)

The advantages of NAD+ injections should exceed any short-lived discomforts that may come with this treatment. Nonetheless, if you encounter complications or severe side effects after receiving a NAD+ injection, seek immediate medical attention. If any side effects persist or worsen, reach out to your healthcare provider for additional guidance and support. Make sure to discuss with your healthcare provider the risks and benefits of using NAD+ injections to ensure they are the best option for you.

Warnings and Contraindications:

People who have a known allergy to NAD+ injection or any of its components should not use this product. NAD+ should not be taken if you have severe liver conditions, cardiovascular disease, active cancer diagnosis as it may influence cellular metabolism and growth. NAD+ is contraindicated in patients who are immunocompromised or have a history of mitochondrial disorders. Prior to using this medicine, the entire medical history and drug history, including over-the-counter drugs, herbs, and supplements, should be reviewed.9,10

Pregnancy & Breastfeeding:

The safety of NAD+ injection has not been evaluated in pregnant women or breastfeeding. Due to this lack of safety data, pregnant women should avoid NAD+ injection.

NAD+ Pricing

DOSE

25MG

50MG

75MG

100MG

3-DOSES

(PER WEEK)

12 Subcutaneous Injections

CHARGE

(PER MONTH)

$ 125.00

$ 175.00

$ 225.00

$ 250.00

Schedule Consultation-Start NAD+

Resources

Johnson S, Imai SI. NAD + biosynthesis, aging, and disease. F1000Res. 2018;7:132. doi:10.12688/f1000research.12120.1
Cantó C, Menzies K, Auwerx J. NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus. Cell Metab. 2015;22(1):31-53. doi:10.1016/j.cmet.2015.05.023
Niño-Narvión J, Rojo-López MI, Martinez-Santos P, et al. NAD+ Precursors and Intestinal Inflammation: Therapeutic Insights Involving Gut Microbiota. Nutrients. 2023;15(13):2992. doi:10.3390/nu15132992
NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway - PubMed. https://pubmed.ncbi.nlm.nih.gov/34530866/
Braidy N, Villalva MD, van Eeden S. Sobriety and Satiety: Is NAD+ the Answer? Antioxidants (Basel). 2020;9(5):425. doi:10.3390/antiox9050425
Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, Guillemin GJ. Age-associated changes inoxidative stress and NAD+ metabolism in human tissue. PLoS One. 2012;7(7):e42357. doi:10.1371/journal.pone.0042357
Verdin E. NAD+ in aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208-1213. doi:10.1126/science.aac4854
Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during aging. Nat Rev Mol Cell Biol. 2021;22(2):119-141. doi:10.1038/s41580-020-00313-x
Hwang ES, Song SB. Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment. Biomolecules. 2020;10(5):687. doi:10.3390/biom10050687
Radenkovic D, Reason, Verdin E. Clinical Evidence for Targeting NAD Therapeutically. Pharmaceuticals (Basel). 2020;13(9):247. doi:10.3390/ph13090247